Which steroid is most commonly associated with hypopigmentation and subcutaneous fat atrophy?

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Triamcinolone is notably linked to hypopigmentation and subcutaneous fat atrophy due to its use in corticosteroid injections for various conditions, including inflammation and pain management. This steroid has a potent anti-inflammatory effect and is commonly utilized in sports medicine to treat joint pain and inflammation.

The localized use of triamcinolone, especially in repeated administrations, can lead to skin changes. The mechanism behind hypopigmentation includes suppression of melanocyte function, which affects the skin's pigmentation. Additionally, triamcinolone’s impact on subcutaneous fat can cause noticeable atrophy in the treated area, where the sterol interferes with local blood flow and cellular function, resulting in fat loss.

This characteristic makes triamcinolone a notable choice in scenarios where such effects are both a consideration and a risk when deciding on treatment and managing patient expectations regarding potential side effects.

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