What specific type of paresthesia is commonly associated with Acetazolamide?

Acetazolamide, a carbonic anhydrase inhibitor, is known to cause a variety of side effects, one of which includes specific types of paresthesia. The correct association is with periorbital paresthesia, which refers to a tingling or numb sensation occurring around the eyes.

The mechanism is thought to be related to changes in acid-base balance and electrolyte shifts caused by the medication, leading to alterations in nerve function, particularly in the trigeminal nerve distribution that supplies the facial region around the eyes. This side effect is particularly noted in patients taking the drug for conditions like glaucoma or altitude sickness.

Identification of this specific type of paresthesia is crucial for healthcare providers as it can help in monitoring patient responses to the medication and adjusting treatment plans accordingly. Understanding the unique side effects helps differentiate between similar presentations caused by other conditions or medications.