What is the NSAID of choice for high-risk cardiac patients?

In managing pain and inflammation for high-risk cardiac patients, naproxen is often considered the NSAID of choice due to its relatively safer profile compared to other nonsteroidal anti-inflammatory drugs. Recent studies suggest that naproxen may carry a lower risk of cardiovascular events than other NSAIDs, such as ibuprofen and diclofenac.

Naproxen has a long half-life, allowing for less frequent dosing and possibly better adherence in patients who may have cardiovascular concerns. Additionally, its anti-inflammatory effects make it effective for various conditions while posing potentially lower risks in terms of thrombosis and other cardiovascular complications associated with NSAID use.

In contrast, ibuprofen and diclofenac are associated with a greater risk of cardiovascular events, especially when used long-term. Although aspirin is often used for cardiovascular protection due to its antiplatelet effects, it does not serve as a primary option for treating pain or inflammation in this context and is not classified as an NSAID in the same way. Thus, for high-risk cardiac patients needing NSAID treatment, naproxen is recommended as it balances efficacy with a more favorable safety profile regarding cardiovascular risks.