What benefit does COX-2 selective NSAIDs have over COX-2 specific NSAIDs?

COX-2 selective NSAIDs are designed to minimize gastrointestinal (GI) side effects compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit both COX-1 and COX-2 enzymes. The primary reason for this is that COX-1 plays a crucial role in maintaining the protective lining of the stomach and intestines. By selectively inhibiting COX-2, which is primarily associated with inflammatory processes, these medications reduce inflammation and pain while significantly decreasing the risk of ulcers and other GI complications often associated with non-selective NSAIDs. This advantage makes COX-2 selective NSAIDs especially suitable for patients who are at higher risk for gastrointestinal issues, such as the elderly or those with a history of GI problems.

Other options do not accurately reflect the primary benefits of COX-2 selective NSAIDs. Increased pain relief and improved efficacy are more reflective of the overall therapeutic action, which can vary based on individual response rather than being a specific benefit of COX-2 selectivity. Lower cost is also not a distinguishing feature of COX-2 selective NSAIDs, as they can often be more expensive than traditional NSAIDs. Thus, the decreased GI side effects remain a key benefit that highlights the clinical